I-Carcinomaofrectum ibizwa ngokuthi umdlavuza we-colorectal, yisimila esiyingozi esivamile epheshaneni lamathumbu, isigameko singesesibili ngemuva komdlavuza wesisu nowomphimbo, ingxenye evame kakhulu yomdlavuza we-colorectal (cishe u-60%).Iningi leziguli lineminyaka engaphezu kuka-40 ubudala, futhi cishe u-15% uneminyaka engaphansi kwengama-30 ubudala.Owesilisa uvame kakhulu, isilinganiso sowesilisa nowesifazane ngu-2-3: 1 ngokusho kokuhlolwa komtholampilo, kutholakala ukuthi ingxenye yomdlavuza we-colorectal ivela kuma-polyps noma i-schistosomiasis;ukuvuvukala okungapheli kwamathumbu, okunye kungabangela umdlavuza;ukudla okunamafutha amaningi kanye namaprotheni amaningi kubangela ukwanda kwe-cholic acid secretion, lokhu kuchithwa ku-unsaturated polycyclic hydrocarbons ngama-anaerobes amathumbu, angabangela nomdlavuza.