I-Hyperthermia ye-Tumor Ablation: I-Pancreatic Cancer's Treatment Case kanye nocwaningo

Umdlavuza we-pancreatic inezinga eliphezulu lokugula kanye nokubikezela okubi.Emisebenzini yomtholampilo, iziguli eziningi zitholakala esiteji esithuthukisiwe, namazinga aphansi okuhlinzwa okuhlinza futhi azikho ezinye izindlela zokwelapha ezikhethekile.Ukusetshenziswa kwe-HIFU kunganciphisa ngempumelelo umthwalo wesimila, ukulawula ubuhlungu, ngaleyo ndlela kwandise ukusinda kwesiguli kanye nokwenza ngcono izinga lokuphila.

Umlando we-Hyperthermiangoba izimila zingalandelelwaemuva eminyakeni engu-5,000 edluleeGibhithe lasendulo, enamarekhodi emibhalweni yesandla yaseGibhithe lasendulo echaza ukusetshenziswa kweukushisa ukwelapha izimila zamabele.Umsunguli weukwelashwa okushisayo, uHippocrates, obhekwa njengoyise wezokwelapha zaseNtshonalanga, waphila eminyakeni engaba ngu-2 500 edlule.

I-Hyperthermia iyindlela yokwelapha ehlanganisa ukusebenzisa imithombo yokushisa ehlukahlukene(okufana ne-radiofrequency, i-microwave, i-ultrasound, i-laser, njll.)ukwandisa izinga lokushisa kwezicubu zesimila ezingeni eliphumelelayo lokwelapha.Lokhu kwenyuka kwezinga lokushisa kuholela ekufeni kwamaseli esimila kuyilapho kunciphisa umonakalo kumaseli avamile.

Ngo-1985, i-US FDA yaqinisekisa ukuhlinzwa, ukwelashwa ngemisebe, i-chemotherapy, i-Hyperthermia, kanye ne-immunotherapy njengobaizindlela zesihlanu ezisebenzayo zokwelapha isimila, emele indlela entsha nephumelelayo.

Isimiso esiyisisekelo siwukusebenzisa amandla angokomzimba ukushisa wonke umzimba noma indawo ethile yomzimba, ukuphakamisa izinga lokushisa lezicubu zesimila libe sezingeni lokwelapha eliphumelelayo nokuyigcina isikhathi esithile.Ngokusebenzisa umehluko wokubekezelela izinga lokushisa phakathi kwezicubu ezijwayelekile namaseli e-tumor, ihlose ukufeza umgomo wokwenza i-tumor cell apoptosis ngaphandle kokulimaza izicubu ezijwayelekile.

Icala 1 Lokwelashwa Kwe-Pancreatic Cancer:

Isiguli: Owesifazane, oneminyaka engama-46 ubudala, isimila emsileni wamanyikwe

Ububanzi besimila bulinganisa u-34mm (anteroposterior), 39mm (transverse), kanye no-25mm (craniocaudal).Ngemuva kwe-ultrasound-guided thermal ablation therapy,i-MRI yokulandelela yembula ukuthi iningi lesimila belingasebenzanga.

Icala 2 Lokwelashwa Kwe-Pancreatic Cancer:

Isiguli: Owesifazane, oneminyaka engama-56 ubudala, umdlavuza we-pancreatic one-metastases eminingi yesibindi

Ukwelashwa ngasikhathi sinye kwakho kokubili ama-metastases e-pancreas nesibindi kusetshenziswa i-ultrasound-guided thermal ablation therapy.I-MRI yokulandelela ibonise ukungasebenzi kwe-tumor, enemajini ecacile nenembile.

Icala lesi-3 lokwelashwa komdlavuza we-pancreatic:

Isiguli: Owesilisa, oneminyaka engama-54 ubudala, umdlavuza we-pancreatic

Ubuhlungu buphele ngokuphelele ezinsukwini ezi-2ngemuva kokwelashwa kwe-HIFU (i-high-intensity focused ultrasound).Isimila sinciphe ngo-62.6% emasontweni ayisi-6, ama-90.1% ezinyangeni ezi-3, futhi amazinga e-CA199 abuyela kwesijwayelekile ezinyangeni eziyi-12.

Icala 4 Lokwelashwa Kwe-Pancreatic Cancer:

Isiguli: Owesifazane, oneminyaka engama-57 ubudala, umdlavuza we-pancreatic

I-Tumor necrosis yenzeke ezinsukwini ezingu-3 ngemva kokwelashwa kwe-HIFU.I-tumor yancipha ngo-28.7% emasontweni angu-6, i-66% ezinyangeni ze-3, futhi ubuhlungu bakhululeka ngokuphelele.

Icala 5 Lokwelashwa Kwe-Pancreatic Cancer:

Isiguli: Owesifazane, oneminyaka engama-41 ubudala, umdlavuza we-pancreatic

Ngemuva kwezinsuku eziyi-9 zokwelashwa kwe-HIFU,ukulandelwa kwe-PET-CT scan kubonise i-necrosis ebanzi phakathi nendawo yesimila.

Icala 6 Lokwelashwa Kwe-Pancreatic Cancer:

Isiguli: Owesilisa, oneminyaka engama-69 ubudala, umdlavuza we-pancreatic

Ukulandelela kwe-PET-CT scan isigamu senyanga ngemva kokwelashwa kwe-HIFUkwembula ukunyamalala okuphelele kwesimila, akukho ukuthatha kwe-FDG, kanye nokwehla okulandelanayo kumazinga e-CA199.

Icala 7 Lokwelashwa Kwe-Pancreatic Cancer:

Isiguli: Owesifazane, oneminyaka engama-56 ubudala, umdlavuza we-pancreatic

I-CT scan yokulandelela usuku olulodwa ngemva kokwelashwa kwe-HIFU kubonisiwe80% ukukhishwa kwesimila.

Icala 8 Lokwelashwa Kwe-Pancreatic Cancer:

Iminyaka engu-57 ubudala, umdlavuza we-pancreatic

Ngemuva kokwelashwa kwe-HIFU, i-CT scan yokulandelelakwembule ukukhishwa okuphelele maphakathi nesimila.