I-Hyperthermia Yokususwa Kwesimila: Icala Nocwaningo Lokwelashwa Komdlavuza We-Pancreatic

Umdlavuza we-pancreatic inezinga eliphezulu lomdlavuza kanye nokubikezela okubi. Emtholampilo, iziguli eziningi zitholakala zisesigabeni esithuthukile, ngamazinga aphansi okuhlinzwa futhi azikho ezinye izindlela zokwelapha ezikhethekile. Ukusetshenziswa kwe-HIFU kunganciphisa ngempumelelo umthwalo wesimila, kulawule ubuhlungu, ngaleyo ndlela kwandise isikhathi sokuphila kwesiguli futhi kuthuthukise ikhwalithi yokuphila.

Umlando we-Hyperthermiaamathumba angalandelelwaeminyakeni engu-5,000 edluleeGibhithe lasendulo, kanye namarekhodi emibhalweni yesandla yasendulo yaseGibhithe achaza ukusetshenziswaukushisa ukwelapha izimila zebele.Umsunguli weukwelashwa ngokushisa, uHippocrates, obhekwa njengoyise wezokwelapha zaseNtshonalanga, waphila eminyakeni engaba ngu-2,500 edlule.

I-Hyperthermia iyindlela yokwelapha ehilela ukusebenzisa imithombo ehlukahlukene yokushisa(njenge-radiofrequency, i-microwave, i-ultrasound, i-laser, njll.)ukwandisa izinga lokushisa kwezicubu zesimila kuze kube sezingeni eliphumelelayo lokwelapha. Lokhu kukhuphuka kwezinga lokushisa kuholela ekufeni kwamangqamuzana esimila ngenkathi kunciphisa umonakalo kumaseli avamile.

Ngo-1985, i-US FDA yaqinisekisa ukuhlinzwa, ukwelashwa ngemisebe, i-chemotherapy, i-Hyperthermia, kanye ne-immunotherapy njengeizindlela zesihlanu ezisebenzayo zokwelapha isimila, emelela indlela entsha nephumelelayo.

Isimiso esiyisisekelo ukusebenzisa amandla angokomzimba ukushisa umzimba wonke noma indawo ethile yomzimba, ukuphakamisa izinga lokushisa lezicubu zesimila liye ezingeni lokwelapha eliphumelelayo futhi uligcine isikhathi esithile. Ngokusebenzisa umehluko wokubekezelela izinga lokushisa phakathi kwezicubu ezivamile namaseli esimila, kuhloswe ukufeza umgomo wokubangela i-apoptosis yamaseli esimila ngaphandle kokulimaza izicubu ezivamile.

Icala 1 Lokwelashwa Komdlavuza We-Pancreatic:

Isiguli: Owesifazane, oneminyaka engu-46 ubudala, unesimila emsileni we-pancreas

Ububanzi besimila bungu-34mm (i-anteroposterior), 39mm (i-transverse), kanye no-25mm (i-craniocaudal). Ngemva kokwelashwa kwe-thermal ablation okuqondiswa yi-ultrasound,I-MRI yokulandelela yembula ukuthi iningi lesimila lalingasebenzi.

Icala 2 Lokwelashwa Komdlavuza We-Pancreatic:

Isiguli: Owesifazane, oneminyaka engu-56 ubudala, umdlavuza we-pancreatic one-metastases yesibindi esiningi

Ukwelashwa ngasikhathi sinye kokubili ukusabalala kwe-pancreatic kanye nesibindi kusetshenziswa ukwelashwa kwe-thermal ablation okuqondiswa yi-ultrasound.I-MRI elandelayo ibonise ukungasebenzi kwesimila, kanye nemingcele ecacile neqondile.

Icala 3 Lokwelashwa Komdlavuza We-Pancreatic:

Isiguli: Owesilisa, oneminyaka engu-54 ubudala, umdlavuza we-pancreatic

Ubuhlungu buphele ngokuphelele zingakapheli izinsuku ezimbilingemva kokwelashwa nge-HIFU (i-high-intensity focused ultrasound).Isimila sehle ngo-62.6% emavikini ayi-6, ngo-90.1% ezinyangeni ezi-3, kanti amazinga e-CA199 abuyele esimweni esijwayelekile ezinyangeni eziyi-12.

Icala 4 Lokwelashwa Komdlavuza We-Pancreatic:

Isiguli: Owesifazane, oneminyaka engu-57 ubudala, umdlavuza we-pancreatic

I-tumor necrosis yenzeke ezinsukwini ezi-3 ngemuva kokwelashwa nge-HIFU.Isimila sancipha ngo-28.7% emavikini ayi-6, ngo-66% ezinyangeni ezi-3, futhi ubuhlungu baphela ngokuphelele.

Icala 5 Lokwelashwa Komdlavuza We-Pancreatic:

Isiguli: Owesifazane, oneminyaka engu-41 ubudala, umdlavuza we-pancreatic

Ngemva kwezinsuku ezingu-9 zokwelashwa kwe-HIFU,Ukuhlolwa kwe-PET-CT okulandelayo kubonise i-necrosis enkulu enkabeni yesimila.

Icala 6 Lokwelashwa Komdlavuza We-Pancreatic:

Isiguli: Owesilisa, oneminyaka engu-69 ubudala, umdlavuza we-pancreatic

Ukuhlolwa kwe-PET-CT okulandelayo ngemva kwesigamu senyanga ngemuva kokwelashwa kwe-HIFUkwembulwe ukunyamalala okuphelele kwesimila, akukho ukuthathwa kwe-FDG, kanye nokwehla okulandelayo kwamazinga e-CA199.

Icala 7 Lokwelashwa Komdlavuza We-Pancreatic:

Isiguli: Owesifazane, oneminyaka engu-56 ubudala, umdlavuza we-pancreatic

Ukuhlolwa kwe-CT okulandelayo ngosuku olulodwa ngemuva kokwelashwa kwe-HIFU kuboniseUkususwa kwesimila okungu-80%.

Icala 8 Lokwelashwa Komdlavuza We-Pancreatic:

Uneminyaka engu-57 ubudala, umdlavuza we-pancreatic

Ngemva kokwelashwa nge-HIFU, kwenziwa i-CT scan elandelayokwembulwe ukuhlanzwa okuphelele enkabeni yesimila.