Muva nje, i-Center for Drug Evaluation (CDE) ye-National Medical Products Administration (NMPA) yaseShayina imemezele ukuthi i-Encorafenib ivunyelwe okwesikhashana ukuthi ibukezwe kuqala. Izosetshenziswa kanye ne-cetuximab kanye nohlelo lwe-FOLFOX chemotherapy njengokwelashwa kokuqala kweziguli ezindala ezine-BRAF V600E-mutant metastatic colorectal cancer.
Lokhu kuphawula intuthuko ebalulekile yokwelapha emphakathini wezokwelapha wamazwe ngamazwe walo mdlavuza okunzima ukuwulapha oqhutshwa ukuguquka kwezakhi zofuzo ezithile.
**Kuyini i-Encorafenib futhi kungani ibalulekile?**
I-Encorafenib iyi-inhibitor ye-BRAF yama-molecule amancane ekhetheka kakhulu, encintisana ne-ATP. Kalula nje, ihlasela ngqo amangqamuzana esimila athwala ukuguqulwa kwe-BRAF V600E, ivimbela ukukhula kwawo nokwanda kwawo. Uma kuqhathaniswa namanye ama-inhibitor e-BRAF avunyiwe ngaphambilini, i-Encorafenib inomsebenzi omude we-pharmacodynamic, okusho ukuthi ihlala isebenza kahle emzimbeni isikhathi eside.
**Idatha Yezokwelapha: Ubufakazi Bokusebenza Kahle Kakhulu**
Ngomhlaka-25 Januwari 2025, *i-Nature Medicine* yashicilela ucwaningo lwezokwelapha lweSigaba sesi-3 lwe-Encorafenib + Cetuximab + chemotherapy yokwelapha umdlavuza we-colorectal oguquliwe yi-BRAF. Ucwaningo lwe-BREAKWATER (NCT04607421) luhlose ukuhlola ukusebenza kahle kwe-encorafenib kanye ne-cetuximab ene-chemotherapy ejwayelekile noma engenayo ezigulini ezine-BRAF V600E-mutant colorectal cancer. Iziguli ezingu-236 ziphelele zafakwa eqenjini lokuhlola kanye nezingu-243 eqenjini lokulawula. Imiphumela ibonise izinga lokuphendula eliqinisekisiwe (cORR) elingu-60.9% eqenjini lokuhlola, kanye neziguli ezi-3 ezithola impendulo ephelele (CR), impendulo engaphelele engu-64 (PR), kanye nesifo esizinzile esingu-31 (SD). Eqenjini lokulawula, i-cORR yayingu-40.0%, kanye ne-CR ezi-2, i-PR engu-42, kanye ne-SD engu-34. Ubude besikhathi sempendulo (DOR) babuyizinyanga ezingu-13.9 kanye nezinyanga ezingu-11.1, ngokulandelana. Ukusinda okumaphakathi okuphelele kwakungalinganiswa eqenjini lokuhlola, uma kuqhathaniswa nezinyanga ezingu-14.6 eqenjini lokulawula.
**Kubantu Abangamazwe Ngamazwe: Isibhedlela iBeijing South Region Oncology International Department Sihlinzeka Ngokutholakala Kokwelashwa Okusezingeni Eliphezulu**
Lolu hlobo lokwelashwa oluthuthukisiwe selungene endleleni yokubuyekezwa okubalulekile eShayina. Ezigulini zamazwe ngamazwe—uma wena noma ilungu lomndeni lifuna izinketho zokwelapha ezingcono—uMnyango Wezizwe Ngezizwe Wesibhedlela SaseBeijing South Region Oncology uzibophezele ekusebenzeni njengebhuloho lobuchwepheshe bezokwelapha obuthuthukisiwe emhlabeni wonke. Silandela eduze intuthuko yemithi yamazwe ngamazwe futhi sinikeza ukubonisana kochwepheshe kanye nosizo lwezokwelapha ezigulini ezifanelekile.
**Xhumana Nathi Namuhla Ukuze Uqale Uhambo Lwakho Lwethemba**
Ungalindi. Wonke amathuba okwelashwa angashintsha indlela yokuphila. Ithimba lethu lezinsizakalo ezikhuluma izilimi eziningi likulungele ukunikeza ukubonisana, ukuhlela ama-aphoyintimenti, kanye nesiqondiso sezokwelapha.
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Ungasithinta nganoma iyiphi yalezi zindlela ezingenhla. Abaxhumanisi bethu beziguli bamazwe ngamazwe bazophendula ngokushesha ukusiza ngokuhlela amarekhodi ezokwelapha, ukuhlolwa kwezinketho zokwelashwa, kanye nanoma yimiphi imibuzo mayelana nokufuna ukunakekelwa eBeijing. UMnyango Wezizwe Ngezizwe Wesibhedlela Se-Beijing South Region Oncology ukulungele ukubhekana nezinselele nawe, ngobungcweti nangozwelo.
Isikhathi sokuthunyelwe: Ephreli-23-2026