UMnu. X uyisiguli esiseminyakeni yakhe yo-40 ubudala esitholakale sine-acral melanoma. Ngemva kokuhlinzwa okukhulu ngemuva kokuxilongwa kwakhe ngo-2015, isimo sakhe sahlala sizinzile iminyaka eyisishiyagalolunye. Ngeshwa, cishe ngonyaka odlule, isifo sakhe saphinde savela ngokusabalala kwamaphaphu womabili. Naphezu kokuthola ukuhlukaniswa kwama-lymph node e-inguinal kanye ne-pelvic kanye nokwelashwa kwesistimu komugqa wesithathu (kufaka phakathi ukwelashwa kwe-PD-1 antibody kanye nokwelashwa okuqondiswe ku-NRAS mutation), ama-tumors ahileleke kakhulu emaphashini, i-groin, izicubu ezingaphansi kodonga lwesisu lwesokudla, kanye nemisipha ye-bilateral erector spinae, okuholela ebuhlungwini obukhulu kanye nokwehla okukhulu kwekhwalithi yokuphila.
Njengamanje, kusenezivivinyo eziningi zemitholampilo zobuchwepheshe obusha bokulwa nomdlavuza eShayina ezifuna iziguli. Ukubonisana ngemithi emisha kanye nobuchwepheshe, ungaxhumana noMnyango Wezizwe Ngezizwe Wesibhedlela iBeijing South Region Oncology.
Inombolo yocingo: 4008803716
I-ID ye-WeChat: 17801183037
Email：myimmnet@163.com
Ekuqaleni kuka-2025, uMnu. X wabamba iqhaza esivivinyweni sokwelashwa kwe-TIL cell (GC101) futhi waqeda ukufakwa kwe-TIL cell ekuqaleni kukaJuni. Nakuba umthwalo wakhe wesimila wawunzima, kanti isilonda esikhulu kunazo zonke sasingama-62 mm, amasonto ayisithupha ngemva kokufakwa, izilonda zakhe eziqondiwe zancipha ngo-31.9%, kanti isilonda esisodwa esikhulu kunazo zonke sancipha cishe ngo-40%. Ukusebenza kahle kokwelashwa kufinyelele impendulo engaphelele (PR). Okubaluleke kakhulu, uMnu. X akazange abhekane nanoma yimiphi imiphumela emibi emikhulu ngemuva kokwelashwa kwe-GC101 TIL, kodwa imiphumela emibi ejwayelekile ehlobene ne-immunotherapy efana nokubanda nomkhuhlane, eyaphela ngokushesha ngokwelashwa okunezimpawu.
Mayelana ne-GC101
I-GC101 iyindlela yokwelapha yemvelo ye-TIL TIL ethuthukiswe kusetshenziswa ipulatifomu yokukhulisa amaseli ye-DeepTIL® ye-Juncell Therapeutics. I-DeepTIL® ivumela ama-TIL ukuba abe namandla ngokwanele kangangokuthi akukho nhlanganisela ye-IL-2 ezodingeka ngemva kokufakwa, futhi ukuqina kokwelashwa kwangaphambi kokwelashwa kungaba phansi.
Njengokwelashwa kokuqala kwe-TIL okudinga ukwelashwa kwangaphambi kokuqina okuphansi kuphela futhi okungenamjovo we-IL-2 emhlabeni, i-GC101 iqinisekiswe ngokusebenza kwayo kahle kanye nokuphepha kwayo okuthuthukisa kakhulu ukuphepha kanye nokufinyeleleka kokwelashwa kwe-TIL.
Mayelana ne-Melanoma
EShayina, izinga lokufa ngenxa ye-melanoma liphezulu futhi izinga lokusabalala kwalo liyakhula unyaka nonyaka. Uma kuqhathaniswa nabantu baseYurophu noma baseMelika, kunomehluko omkhulu ezicini ze-melanoma ngesiShayina: cishe u-90% we-melanoma uvela esikhumbeni phakathi kwabantu baseYurophu nabaseMelika. E-Asia, cishe u-50% we-melanoma uvela esikhumbeni kanye no-20-30% esikhumbeni. Ngokuphambene nalokho, i-melanoma yohlobo lwe-end kanye ne-mucosal inesimo esibi kakhulu.
Njengamanje, kusenezivivinyo eziningi zemitholampilo zobuchwepheshe obusha bokulwa nomdlavuza eShayina ezifuna iziguli. Ukubonisana ngemithi emisha kanye nobuchwepheshe, ungaxhumana noMnyango Wezizwe Ngezizwe Wesibhedlela iBeijing South Region Oncology.
Inombolo yocingo: 4008803716
I-ID ye-WeChat: 17801183037
Email：myimmnet@163.com
Isikhathi sokuthunyelwe: Agasti-07-2025