Ekuqaleni kuka-2026, insimu yokwelapha i-oncology yaseShayina ifinyelele intuthuko enkulu. Ngomhlaka-5 Januwari, i-China National Medical Products Administration (NMPA) yagunyaza ngokusemthethweni umuthi oqondiswe esizukulwaneni esisha i-Repotrectinib wokwelapha iziguli ezindala ezinezimila eziqinile ezigcina i-neurotrophic tyrosine receptor kinase (NTRK) gene fusions. Lokhu kuvunyelwa kuletha ithemba elisha kanye nezinketho ezigulini eziningi ezinezimila eziqinile ezithuthukile ezibhekene nezinselele zokwelapha, ikakhulukazi lezo ezihlulekile ukwelashwa kwangaphambilini noma ezingenazo izinketho zokwelapha ezisebenzayo.
**Mayelana ne-Ocapler® (Repotrectinib): Umuthi Oqondiswe Esizukulwaneni Esisha, Onamandla, Noqondile**
I-Ocapler® (i-Repotrectinib) iyi-tyrosine kinase inhibitor (TKI) yesizukulwane esisha eyenzelwe ngokukhethekile ukuhlasela ngqo ukuhlanganiswa kwezakhi zofuzo ze-ROS1 kanye ne-NTRK oncogenic. Ezigulini ezinezimila eziqinile (kufaka phakathi umdlavuza wamaphaphu ongewona amangqamuzana amancane, njll.) ezithwala lezi zinguquko zezakhi zofuzo, i-Repotrectinib ikhombisa ukusebenza kahle okukhulu ngisho nangemva kokumelana nezindlela zokwelapha eziqondiwe ngaphambilini. Iphinde ilawule ngempumelelo ukusabalala kobuchopho, inikeze izinzuzo zokwelapha ezihlala isikhathi eside.
**Idatha Eqinile Ebonisa Ukusebenza Okuhle Kakhulu**
Ukuvunyelwa kwe-NMPA kusekelwe ocwaningweni olubalulekile lweSigaba 1/2 se-TRIDENT-1 somhlaba wonke. Imiphumela iyakhuthaza:
- **Ezigulini ezazilashwe ngaphambilini ngokwelashwa okuqondiswe ku-TRK:** Izinga lokuphendula eliqondile (ORR) lifinyelele ku-50%, kanti izinga lokulawula izifo (DCR) lingu-42%.
- **Kubantu abangenalo ulwazi lokwelashwa abangazange belashwe ngaphambilini ngokwelashwa okuqondiswe ku-TRK:** Ukusebenza kahle kuyamangalisa nakakhulu, ngesilinganiso sokuphendula esiqondile siphezulu njengo-58%, kufaka phakathi izinga lokuphendula okuphelele (CR) elingu-15%, okusho ukuthi izimila zanyamalala ngokuphelele kwezinye iziguli. Okuphawulekayo ukuthi, ama-83% abaphenduli baqhubeka nokuzuza ngonyaka owodwa kamuva.
Le mininingwane ikhombisa ngokusobala umsebenzi we-Repotrectinib onamandla futhi ohlala isikhathi eside wokulwa nomdlavuza, kanye nephrofayili yokuphepha elawulekayo, ezigulini ezine-NTRK fusion-positive solid tumors.
**UMnyango Wezizwe Ngezizwe Wesibhedlela Se-Oncology saseBeijing South Region: Isango Lakho Lokunakekelwa Kwempilo Komhlaba**
Njengenye yezikhungo zokuxilonga nokwelapha umdlavuza ezihamba phambili eShayina, uMnyango Wezangaphandle Wesibhedlela iBeijing South Region Oncology uhlala uphambili ekulweni nomdlavuza. UMnyango Wezangaphandle Wezokwelapha uyifasitela lethu elizinikele leziguli ezivela emhlabeni wonke, ezizinikele ekuhlinzekeni ngezinsizakalo zezokwelapha ezisezingeni eliphezulu, ezenzelwe umuntu ngamunye ezihambisana nezindinganiso zomhlaba wonke.
**Kungani Sikhethe?**
1. **Ukufinyelela Ekwelashweni Okusezingeni Eliphezulu Komhlaba:** Silandela eduze ukuvunyelwa kwemithi kwakamuva komhlaba wonke (njengokuvunyelwa kwakamuva kwe-Repotrectinib), siqinisekisa ukuthi iziguli zamazwe ngamazwe zingakwazi ukufinyelela izinketho zokwelapha ezithuthukisiwe eShayina ezihambisana nalezo ezitholakala e-United States, eYurophu nakwezinye izifunda.
2. **Ithimba Lochwepheshe Abahlukahlukene (MDT):** Sinethimba lochwepheshe abanolwazi emikhakheni eyahlukene yezimila eziqinile, okuhlanganisa umdlavuza wamaphaphu, i-sarcoma, kanye nomdlavuza we-thyroid, elikwazi ukuhlinzeka ngokuxilongwa okunembile kanye nokuhlela ukwelashwa okuphelele kweziguli ezinezakhi zofuzo ezingavamile njenge-NTRK.
3. **Izinsizakalo Zeziguli Zamazwe Ngamazwe Ezisebenza Ngokuphelele:** Kusukela ekubonisaneni kokuqala, ukubuyekezwa kwamarekhodi ezokwelapha, ukuhlela ama-aphoyintimenti, kanye nokubonisana kochwepheshe kuya emalungiselelweni okwelashwa, ukwesekwa kokulaliswa esibhedlela, kanye nokunakekelwa kokulandelela, sinikeza izinsizakalo ezingenazihibe, ezikhuluma izilimi eziningi, nezinakekelayo kuyo yonke inqubo.
4. **Ukuhlanganiswa Kwezokwelapha Okulula Kokunqamula Imingcele:** Siyaqonda ngokujulile izidingo zokuhamba nokuxhumana zeziguli zamazwe ngamazwe futhi singanikeza usizo oludingekayo ukuqinisekisa ukuthi uhambo lwakho lwezokwelapha luhamba kahle futhi alukhathazeki.
**Xhumana Nathi Manje Ukuze Uqale Uhambo Lwakho Lokwelashwa Okunembile**
Uma wena noma abathandekayo bakho nifuna ithemba elisha lokwelashwa kwezimila eziqinile ze-NTRK fusion-positive, sicela usithinte ngokushesha. Ithimba lethu lochwepheshe loMnyango Wezokwelapha Womhlaba Wonke likulungele ukuhlola ukufaneleka kwakho futhi linikeze isiqondiso sezokwelapha esinemininingwane.
- **Ucingo Lokuphuthumayo Lweziguli Zamazwe Ngamazwe:** 400-880-3716
- **WeChat/WhatsApp:** +86 17801183037 (I-ID ye-WeChat: 17801183037)
- **I-imeyili:**
100085_010@163.com
myimmnet@163.com
*(Sicela uqaphele: Ukuze uqinisekise ukusebenza kahle kokuxhumana, uma uthumela amarekhodi ezokwelapha, sicela ukopishe womabili amakheli e-imeyili bese ufaka incazelo emfushane yesimo.)*
**Icebiso Lesenzo:**
Sicela ulungiselele imibiko efanele yezifo, imibiko yokuhlolwa kwezakhi zofuzo (ikakhulukazi leyo equkethe imiphumela yokuhlanganiswa kwezakhi zofuzo ze-NTRK), kanye namarekhodi okwelashwa angaphambilini ukuze unikeze uma usithinta. Lokhu kuzosiza ochwepheshe bethu ukuthi benze ukuhlolwa kokuqala okusheshayo nokunembile.
UMnyango Wezizwe Ngezizwe Wesibhedlela Se-Beijing South Region Oncology uzibophezele ekuvikeleni impilo kanye nezimpilo zeziguli emhlabeni wonke ngobuchwepheshe bezokwelapha kanye nokunakekelwa okufudumele nokunesihawu. Silangazelela ukubuza kwakho.
Isikhathi sokuthunyelwe: Jan-08-2026