Ngomhlaka-31 kuJulayi 2025, i-ImmuneOnco Biopharmaceuticals imemezele idatha yokuqala yokuphepha nokusebenza kahle evela ocwaningweni lwe-IMM2510 oluvulekile lwesigaba sesi-2 oluhlanganisa ne-chemotherapy yeziguli ezisebenza phambili ezinomdlavuza wamaphaphu ongewona omncane (i-NSCLC) oqhutshwe eShayina.
Kusukela ngomhlaka-1 kuJulayi 2025, iziguli ezingu-33 zanikezwa umthamo ongu-10 mg/kg, kanti iziguli ezingu-21 zathola okungenani ukuhlolwa okukodwa kwesimila (ukusebenza kahle kuyahlolwa). Izimpendulo ezingaphelele zabonwa ku-62% weziguli ezihlolwa ukusebenza kahle, okuhlanganisa izimpendulo ezingaphelele ku-80% (8/10) weziguli ezine-NSCLC ene-squamous kanye no-46% (5/11) weziguli ezine-NSCLC engeyona i-squamous. Iningi leziguli ezihlolwa ukusebenza kahle lathola ukuhlolwa okukodwa kwesimila kuphela ekunqunyweni kwedatha. I-ImmuneOnco ilindele ukwethula idatha yokuphepha nokusebenza kahle esivivinyweni sokuhlanganiswa kwe-chemotherapy se-IMM2510 ku-NSCLC engaphambili engqungqutheleni yezokwelapha yesikhathi esizayo.
Iphrofayili yokuphepha ye-IMM2510 isekela ukuthuthukiswa okuqhubekayo kwezokwelapha, ngaphandle kobuthi obukhawulela umthamo obubonwe ezigulini ezingu-33 ezihlolwayo zokuphepha. Kulezi ziguli, bekungekho izehlakalo ezimbi ezihlobene nokwelashwa (TRAE) eziholele ekunciphiseni umthamo noma ekufeni, kanye ne-TRAE eyodwa kuphela eholele ekuyekeni kwemithi. Ama-TRAE avame kakhulu eBangeni lesi-3+ ayeyi-hematological, kanye nemiphumela engavamile yezokwelapha. Izehlakalo ezimbi ezivame ukuhlotshaniswa nokuvinjelwa kwe-VEGF (isb., umfutho wegazi ophakeme, i-proteinuria, i-hemoptysis) kanye nezehlakalo ezimbi ezihlobene nokuzivikela komzimba zazingavamile futhi ngokuvamile ziphansi, kanti ukusabela okuhlobene nokufakwa cishe kwakuphansi.
Njengamanje, kusenezivivinyo eziningi zemitholampilo zobuchwepheshe obusha bokulwa nomdlavuza eShayina ezifuna iziguli. Ukubonisana ngemithi emisha kanye nobuchwepheshe, ungaxhumana noMnyango Wezizwe Ngezizwe Wesibhedlela iBeijing South Region Oncology.
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Isikhathi sokuthunyelwe: Agasti-05-2025