Ukwelashwa Kwesihlanu Kwama-Tumor - Hyperthermia
Uma kukhulunywa ngokwelashwa kwesimila, abantu bavame ukucabanga ngokuhlinzwa, i-chemotherapy, nokwelashwa ngemisebe.Kodwa-ke, ezigulini ezinomdlavuza ezisezingeni eliphezulu ezilahlekelwe ithuba lokuhlinzwa noma ezesaba ukungabekezelelani ngokomzimba kokwelashwa ngamakhemikhali noma ukukhathazeka ngemisebe yokwelashwa ngemisebe, izindlela zazo zokwelapha kanye nesikhathi sokuphila kungase kulinganiselwe kakhulu.
I-Hyperthermia, ngaphezu kokusetshenziswa njengendlela yokwelapha ezimele yamathumba, ingabuye ihlanganiswe nokwelashwa ngamakhemikhali, ukwelapha ngemisebe, imithi yendabuko yamaShayina, nokunye ukwelashwa ukuze kwakheke ukuhambisana kwezinto eziphilayo.Ikhulisa ukuzwela kweziguli ku-chemotherapy, ekwelapheni ngemisebe, kanye nemithi yendabuko yamaShayina, okuholela ekuqedweni okuphumelelayo kwamangqamuzana abulalayo esimila.I-Hyperthermia ithuthukisa izinga lempilo futhi yandise impilo yeziguli ngenkathi inciphisa imiphumela emibi ebangelwa ukwelapha ngemisebe kanye nokwelashwa ngamakhemikhali.Ngakho-ke, kubizwa ngokuthi"i-green therapy"ngumphakathi wezokwelapha wamazwe ngamazwe.
I-RF8 Hyperthermia System ene-Ultra-High-Speed Electromagnetic Waves
I-THERMOTRON-RF8iwuhlelo lwe-tumor hyperthermia olwakhiwe ngokuhlanganyela yi-Japan National Institute of Science and Technology, i-Kyoto University School of Medicine, kanye ne-Yamamoto VINITA Corporation.
*I-RF-8 ineminyaka engaphezu kwengama-30 yokuhlangenwe nakho komtholampilo.
*Isebenzisa ubuchwepheshe bomhlaba obuyingqayizivele be-8MHz electromagnetic wave.
*Isistimu yayo yokulawula izinga lokushisa enembayo inomkhawulo wephutha ongaphansi kuka-+(-) 0.1 degrees Celsius.
Lolu hlelo lulawula ngempumelelo imisebe ye-electromagnetic wave ngaphandle kokudinga ukuvikelwa kwe-electromagnetic.
Isebenzisa umklamo ophumelelayo osizwa ngekhompuyutha wokuhlela ukwelashwa nokuqapha ngesikhathi senqubo yokwelapha.
Izimpawu ze-Hyperthermia:
Ikhanda Nentamo, Izitho:Izimila zekhanda nentamo, izimila ezimbi zamathambo, izimila ezithambile zezicubu.
I-Thoracic Cavity:Umdlavuza wamaphaphu, umdlavuza womminzo, umdlavuza webele, i-mesothelioma eyingozi, i-lymphoma eyingozi.
I-Pelvic Cavity:Umdlavuza wezinso, umdlavuza wesinye, umdlavuza wesinye, umdlavuza wamasende, umdlavuza wesitho sangasese sowesifazane, umdlavuza wesibeletho, umdlavuza we-endometrial, umdlavuza wesibeletho.
I-Abdominal Cavity:Umdlavuza wesibindi, umdlavuza wesisu, umdlavuza we-pancreatic, umdlavuza we-colorectal.
Izinzuzo ze-Hyperthermia Ihlanganiswe nezinye izindlela zokwelapha:
I-Hyperthermia:Ngokushisisa izicubu ezijulile endaweni okuhloswe kuyo ukuthi zibe ngama-degree Celsius angama-43, ukuguqulwa kwamaprotheni kwenzeka kumaseli omdlavuza.Ukwelashwa okuningi kungaholela ku-apoptosis yamangqamuzana omdlavuza futhi kuguqule indawo yezicubu zendawo kanye ne-metabolism, okuholela ekwandeni kokukhiqizwa kwamaprotheni okushisa okushisa nama-cytokines, ngaleyo ndlela kukhulise umsebenzi wokuzivikela komzimba.
I-Hyperthermia + Chemotherapy (I-Intravenous):Kusetshenziswa ingxenye eyodwa kwezintathu kuya kwengxenye yomthamo ojwayelekile we-chemotherapy, ukuphathwa kwe-intravenous okuvunyelanisiwe kwenziwa lapho izinga lokushisa lomzimba elijulile lifinyelela ku-43 degrees Celsius.Lokhu kuthuthukisa ukugxila kwezidakamizwa zendawo kanye nokusebenza kahle kuyilapho kunciphisa imiphumela emibi ye-chemotherapy.Ingazanywa njengendlela yokwelapha ngamakhemikhali “okwehlisiwe” ezigulini ezingafanele ukwelashwa ngamakhemikhali okungokwesiko ngenxa yezimo zazo zomzimba.
I-Hyperthermia + Perfusion (I-Thoracic kanye ne-Abdominal Effusions):Ukwelapha i-pleural ehlobene nomdlavuza ne-peritoneal effusions kuyinselele.Ngokuqhuba kanyekanye i-hyperthermia kanye nokugcoba ama-chemotherapeutic agents ngokusebenzisa amashubhu okukhipha amanzi, amangqamuzana omdlavuza angabhujiswa, kunciphise ukunqwabelana koketshezi futhi kudambise izimpawu zesiguli.
I-Hyperthermia + Ukwelashwa Kwemisebe:Ukwelapha ngemisebe akusebenzanga kangako kumaseli esigabeni sika-S, kodwa lawa maseli azwela ukushisa.Ngokuhlanganisa i-hyperthermia phakathi kwamahora amane ngaphambi noma ngemva kokwelashwa ngemisebe, ukwelashwa kungaqinisekiswa kuwo wonke amaseli ezigabeni ezihlukene zomjikelezo weseli ngosuku olufanayo, okuholela ekuncishisweni okungaba ngu-1/6 komthamo wemisebe.
Izimiso kanye Nemisuka Yokwelashwa Kwe-Hyperthermia
Igama elithi “Hyperthermia” livela egameni lesiGreki, elisho “ukushisa okukhulu” noma “ukushisa ngokweqile.”Kubhekiselwa endleleni yokwelapha lapho kusetshenziswa khona imithombo ehlukene yokushisa (i-radiofrequency, i-microwave, i-ultrasound, i-laser, njll.) ukuze kukhushulwe izinga lokushisa lezicubu zesimila libe sezingeni lokwelapha eliphumelelayo, okubangela ukufa kweseli yesimila kuyilapho kusindisa amaseli avamile emonakalweni.I-Hyperthermia ayigcini nje ngokubulala amangqamuzana esimila kodwa futhi iphazamisa ukukhula nendawo yokuzala yamangqamuzana esimila.
Umsunguli we-hyperthermia angalandelelwa emuva ku-Hippocrates eminyakeni engu-2500 edlule.Ngokuthuthuka okude, amacala amaningana alotshwe emithini yesimanje lapho izimila zanyamalala ngemva kokuba iziguli zithole umkhuhlane omkhulu.Ngo-1975, ku-International Symposium on Hyperthermia eyayibanjelwe eWashington, DC, i-hyperthermia yaqashelwa njengendlela yesihlanu yokwelapha izimila eziyingozi.Yathola isitifiketi se-FDA ngo-1985.Ngo-2009, uMnyango Wezempilo waseShayina wakhipha "Ukucaciswa Kwezokuphatha Kwe-Local Tumor Hyperthermia kanye Nobuchwepheshe Obusha," eqinisa i-hyperthermia njengenye yezindlela ezibalulekile zokwelashwa okuphelele komdlavuza, okuhambisana nokuhlinzwa, ukwelashwa ngemisebe, i-chemotherapy, kanye ne-immunotherapy.
Ukubuyekezwa Kwecala
Icala loku-1: Isiguli esine-metastasis yesibindi esivela ku-renal cell carcinomawathola i-immunotherapy iminyaka engu-2 futhi wathola ingqikithi yamaseshini angu-55 ahlangene we-hyperthermia.Njengamanje, ukuthwebula izithombe kubonisa ukunyamalala kwezicubu, izimpawu ze-tumor ziye zancipha emazingeni avamile, futhi isisindo sesiguli sikhuphuke sisuka kumakhilogremu angu-110 saya kumakhilogremu angu-145.Bangaphila ukuphila okuvamile.
Icala 2: Isiguli esine-pulmonary mucinous adenocarcinomawabhekana nokuthuthuka kwezifo ngemva kokuhlinzwa, ukwelashwa ngemisebe, ukwelashwa okuhlosiwe, kanye ne-immunotherapy.Umdlavuza wawune-metastasis esabalele ngokuphuma kwe-pleural.Ukwenyuka kokwelashwa kwe-ion yesivinini kuhlanganiswe ne-Advanced immunotherapy kwaqalwa emasontweni amathathu edlule.Ukwelashwa akuzange kubonise imiphumela emibi, futhi isiguli asinakho ukungakhululeki okuphawulekayo.Lokhu kwelashwa kumelela ithuba lokugcina lesiguli.
Icala lesi-3: Isiguli somdlavuza wangemuva kokuhlinzwaokwadingeka ayeke ukwelashwa okuhlosiwe ngenxa yokulimala okukhulu kwesikhumba.Ngemva kokuqeda iseshini eyodwa yokwelashwa kwe-ion esheshayo, isiguli sazuza i-11amakhilogremu ngesisindo.
Isikhathi sokuthumela: Aug-04-2023