Ukwelashwa Kwesihlanu Kwama-Tumors - I-Hyperthermia
Uma kukhulunywa ngokwelashwa kwesimila, abantu bavame ukucabanga ngokuhlinzwa, ukwelashwa ngamakhemikhali, kanye nokwelashwa ngemisebe. Kodwa-ke, ezigulini zomdlavuza ezisesigabeni esiphambili ezilahlekelwe yithuba lokuhlinzwa noma ezesaba ukungabekezeleli ngokomzimba ukwelashwa ngamakhemikhali noma ukukhathazeka ngemisebe evela ekwelashweni ngemisebe, izinketho zazo zokwelashwa kanye nesikhathi sokusinda zingase zibe zilinganiselwe kakhulu.
I-Hyperthermia, ngaphezu kokusetshenziswa njengokwelashwa okuzimele kwama-tumors, ingahlanganiswa ne-chemotherapy, ukwelashwa ngemisebe, imithi yendabuko yaseShayina, kanye nezinye izindlela zokwelapha ukuze kudalwe ukuhambisana kwezinto eziphilayo. Yandisa ukuzwela kweziguli ku-chemotherapy, ukwelashwa ngemisebe, kanye nemithi yendabuko yaseShayina, okuholela ekuqedweni okuphumelelayo kwamaseli ama-tumors amabi. I-Hyperthermia ithuthukisa ikhwalithi yokuphila futhi yandisa impilo yeziguli ngenkathi inciphisa imiphumela emibi ebangelwa ukwelashwa ngemisebe kanye ne-chemotherapy. Ngakho-ke, ibizwa ngokuthi"Ukwelashwa okuluhlaza"ngumphakathi wezokwelapha wamazwe ngamazwe.
Uhlelo lwe-RF8 Hyperthermia olunamagagasi kagesi asheshayo kakhulu
I-THERMOTRON-RF8uhlelo lwe-tumor hyperthermia olwakhiwe ngokubambisana yi-Japan National Institute of Science and Technology, i-Kyoto University School of Medicine, kanye ne-Yamamoto VINITA Corporation.
*I-RF-8 ineminyaka engaphezu kwengu-30 yesipiliyoni sezokwelapha.
*Isebenzisa ubuchwepheshe obuyingqayizivele be-8MHz electromagnetic wave emhlabeni.
*Uhlelo lwayo lokulawula izinga lokushisa olunembile lunesilinganiso samaphutha esingaphansi kuka-+(-) 0.1 degrees Celsius.
Lolu hlelo lulawula ngempumelelo imisebe yamagagasi kagesi ngaphandle kokudinga ukuvikelwa kwe-electromagnetic.
Isebenzisa umklamo osebenza kahle osizwa yikhompyutha wokuhlela ukwelashwa nokuqapha ngesikhathi senqubo yokwelapha.
Izimpawu ze-Hyperthermia:
Ikhanda Nentamo, Izitho Zomzimba:Izimila zekhanda nentamo, izimila zamathambo ezinobungozi, izimila zezicubu ezithambile.
Umgodi Wesifuba:Umdlavuza wamaphaphu, umdlavuza womphimbo, umdlavuza webele, i-mesothelioma embi, i-lymphoma embi.
Umgodi Wesinqe:Umdlavuza wezinso, umdlavuza wesinyi, umdlavuza wendlala yesitho sangasese sowesifazane, umdlavuza wesibeletho, umdlavuza we-endometrial, umdlavuza wesibeletho.
Umgodi Wesisu:Umdlavuza wesibindi, umdlavuza wesisu, umdlavuza we-pancreatic, umdlavuza we-colorectal.
Izinzuzo ze-Hyperthermia Zihlanganiswe Nezinye Izindlela Zokwelapha:
Ukushisa okuphezulu:Ngokushisa izicubu ezijulile endaweni okuqondiswe kuyo kufinyelele kuma-degree Celsius angu-43, ukubola kwamaprotheni kwenzeka kumaseli omdlavuza. Ukwelashwa okuningi kungaholela ekuqhekekeni kwamangqamuzana omdlavuza futhi kushintshe indawo yezicubu zasendaweni kanye nokuguqulwa kwe-metabolism, okuholela ekukhiqizweni okwandisiwe kwamaprotheni okushisa kanye nama-cytokine, ngaleyo ndlela kukhuliswe umsebenzi wokuzivikela komzimba.
Ukushisa Okuphezulu + Ukwelashwa Nge-Chemotherapy (Nge-Intravenous):Kusetshenziswa ingxenye eyodwa kwezintathu kuya kwengxenye yomthamo we-chemotherapy ojwayelekile, ukuphathwa ngemithambo yegazi okuhambisanayo kwenziwa lapho izinga lokushisa lomzimba elijulile lifinyelela kuma-degree Celsius angu-43. Lokhu kuthuthukisa ukuhlushwa kwemithi yendawo kanye nokusebenza kahle ngenkathi kunciphisa imiphumela emibi ye-chemotherapy. Kungazanywa njengenketho ye-chemotherapy "encishisiwe" yeziguli ezingafaneleki i-chemotherapy yendabuko ngenxa yezimo zazo zomzimba.
I-Hyperthermia + Ukugeleza (Ukugeleza Kwesifuba Nesisu):Ukwelapha ukuphuma kwegazi okuhlobene nomdlavuza kanye nokukhishwa kwegazi okubangelwa umdlavuza kuyinselele. Ngokusebenzisa i-hyperthermia kanye nokuthulula ama-chemotherapy agents ngamapayipi okukhipha amanzi ngesikhathi esifanayo, amangqamuzana omdlavuza angabhujiswa, kuncishiswe ukuqongelela koketshezi futhi kuncishiswe izimpawu zesiguli.
Ukwelashwa Nge-Hyperthermia + Ngemisebe:Ukwelashwa ngemisebe akusebenzi kahle ngokumelene namaseli esigabeni se-S, kodwa lawa maseli ayazwela ekushiseni. Ngokuhlanganisa i-hyperthermia zingakapheli amahora amane ngaphambi noma ngemva kokwelashwa ngemisebe, ukwelashwa kungaqinisekiswa kuwo wonke amaseli ezigabeni ezahlukene zomjikelezo weseli ngosuku olufanayo, okuholela ekunciphiseni okungenzeka kube yi-1/6 komthamo wemisebe.
Izimiso kanye Nemvelaphi Yokwelashwa Kwe-Hyperthermia
Igama elithi “Hyperthermia” livela egameni lesiGreki, elisho “ukushisa okuphezulu” noma “ukushisa ngokweqile.” Libhekisela endleleni yokwelapha lapho kusetshenziswa khona imithombo yokushisa ehlukene (i-radiofrequency, i-microwave, i-ultrasound, i-laser, njll.) ukuze kukhushulwe izinga lokushisa kwezicubu zesimila liye ezingeni eliphumelelayo lokwelapha, okubangela ukufa kwamangqamuzana esimila ngenkathi kulondolozwa amangqamuzana avamile ekulimaleni. I-Hyperthermia ayibulali nje kuphela amangqamuzana esimila kodwa futhi iphazamisa indawo yokukhula kanye nokuzala kwamangqamuzana esimila.
Umsunguli we-hyperthermia angalandelelwa emuva kuHippocrates eminyakeni engu-2500 eyedlule. Ngokuthuthuka isikhathi eside, kuye kwabhalwa amacala amaningana kwezokwelapha zanamuhla lapho izimila zanyamalala khona ngemva kokuba iziguli zithole umkhuhlane ophakeme. Ngo-1975, e-International Symposium on Hyperthermia eyayibanjelwe eWashington, DC, i-hyperthermia yaqashelwa njengendlela yesihlanu yokwelapha izimila ezinobungozi.Yathola isitifiketi se-FDA ngo-1985.Ngo-2009, uMnyango Wezempilo waseShayina wakhipha i-“Management Specification for Local Tumor Hyperthermia and New Technologies,” eqinisa i-hyperthermia njengenye yezindlela ezibalulekile zokwelapha umdlavuza ngokuphelele, kanye nokuhlinzwa, ukwelashwa ngemisebe, i-chemotherapy, kanye ne-immunotherapy.
Ukubuyekezwa Kwecala
Icala 1: Isiguli esine-metastasis yesibindi esivela ku-renal cell carcinomawelashwa nge-immunotherapy iminyaka emi-2 futhi wathola izilinganiso ezingu-55 ezihlanganisiwe ze-hyperthermia. Njengamanje, izithombe zibonisa ukunyamalala kwezimila, izimpawu zesimila zehle zaya emazingeni ajwayelekile, kanti isisindo sesiguli sikhuphuke sisuka kumakhilogremu angu-110 saya kumakhilogremu angu-145. Bangaphila impilo evamile.
Icala 2: Isiguli esine-pulmonary mucinous adenocarcinomababhekane nokuqhubeka kwesifo ngemva kokuhlinzwa, ukwelashwa ngemisebe, ukwelashwa okuqondiwe, kanye nokwelashwa nge-immunotherapy. Umdlavuza wawusakazeke kabanzi nge-pleural effusion. Ukwelashwa kwe-ion okusheshayo okwandayo kuhlanganiswe nokwelashwa nge-immunotherapy okuthuthukisiwe kwaqalwa emasontweni amathathu edlule. Ukwelashwa akubonisi imiphumela emibi, futhi isiguli asinakho ukungakhululeki okukhulu. Lokhu kwelashwa kumelela ithuba lokugcina lesiguli.
Icala 3: Isiguli esinomdlavuza we-colon ngemuva kokuhlinzwaokwadingeka bayeke ukwelashwa okuqondiwe ngenxa yomonakalo omkhulu wesikhumba. Ngemva kokuqeda iseshini eyodwa yokwelashwa nge-ion okusheshayo, isiguli sathola i-11isisindo esingamakhilogremu.
Isikhathi sokuthunyelwe: Agasti-04-2023