Ngomhlaka-22 Agasti 2025, i-Datopotamab deruxtecan (Dato-DXd; Datroway) ithole imvume eShayina yokwelapha iziguli ezindala ezine-hormone receptor-positive engasuswa noma e-metastatic, i-HER2-negative (immunohistochemistry [IHC] 0, IHC 1+, noma i-IHC 2+/in situ hybridization [ISH] negative) umdlavuza webele ezike zathola ukwelashwa kwe-endocrine kanye nokwelashwa okungenani okukodwa kwe-chemotherapy endaweni ethuthukisiwe.
Njengamanje, kusenezivivinyo eziningi zemitholampilo zobuchwepheshe obusha bokulwa nomdlavuza eShayina ezifuna iziguli. Ukubonisana ngemithi emisha kanye nobuchwepheshe, ungaxhumana noMnyango Wezizwe Ngezizwe Wesibhedlela iBeijing South Region Oncology.
Inombolo yocingo: 4008803716
I-ID ye-WeChat: 17801183037
Email：myimmnet@163.com
Lokhu kuvunywa kusekelwe emiphumeleni emihle yocwaningo lwe-TROPION-Breast01 lwesigaba sesi-3 somhlaba wonke. Ucwaningo lwe-TROPION-Breast01 oluvulekile, oluhleliwe lwesigaba sesi-3, luhlole i-trophoblast cell surface antigen 2-directed antibody-drug conjugate datopotamab deruxtecan (Dato-DXd) uma kuqhathaniswa nokukhetha komcwaningi kwe-chemotherapy (ICC) kumdlavuza webele we-hormone receptor–positive/human epidermal growth factor receptor 2–negative (HR+/HER2–).
Iziguli zabelwa ngokungahleliwe ku-Dato-DXd (n = 365) noma ku-ICC (n = 367). I-Dato-DXd inciphise kakhulu ingozi yokuqhubeka noma yokufa uma kuqhathaniswa ne-ICC (PFS by BICR hazard ratio [HR], 0.63 [95% CI, 0.52 kuya ku-0.76]; P < .0001). Inzuzo ye-PFS eqhubekayo yabonwa kuwo wonke amaqembu amancane. Nakuba idatha ye-OS yayingakavuthwa, kwabonakala ukuthambekela okukhuthaza i-Dato-DXd (HR, 0.84 [95% CI, 0.62 kuya ku-1.14]). Izinga lezehlakalo ezimbi ezihlobene nokwelashwa (ama-TRAE) ebanga ≥3 nge-Dato-DXd laliphansi kune-ICC (20.8% v 44.7%). Ama-TRAE avame kakhulu (noma yiliphi ibanga; ibanga ≥3) kwakuyisicanucanu (51.1%; 1.4%) kanye ne-stomatitis (50%; 6.4%) ene-Dato-DXd kanye ne-neutropenia (igama eliqoqwe ngamaqembu, 42.5%; 30.8%) ene-ICC.
Iziguli ezithola i-Dato-DXd zibe nokuthuthuka okuphawulekayo ngokwezibalo nokubalulekile emtholampilo ku-PFS kanye nephrofayili yokuphepha enhle nephathekayo, uma kuqhathaniswa ne-ICC.
Njengamanje, kusenezivivinyo eziningi zemitholampilo zobuchwepheshe obusha bokulwa nomdlavuza eShayina ezifuna iziguli. Ukubonisana ngemithi emisha kanye nobuchwepheshe, ungaxhumana noMnyango Wezizwe Ngezizwe Wesibhedlela iBeijing South Region Oncology.
Inombolo yocingo: 4008803716
I-ID ye-WeChat: 17801183037
Email：myimmnet@163.com
Isikhathi sokuthunyelwe: Agasti-26-2025