Muva nje, ucwaningo lwe-Antengene's Phase I/II CLINCH lwe-ATG-022 (i-CLDN18.2 antibody-drug conjugate), isiguli esikhulile esinomdlavuza wesisu othuthukile esiye sathuthuka emigqeni eminingi ye-chemotherapy, i-immunotherapy kanye nokwelashwa okuqondisiwe naphezu kokwelashwa okubanzi kwe-metastases sithole impendulo ephelele (CR) ngemuva kokwelashwa okukodwa kwe-ATG-022. Isimo sesiguli sokungabi naso isimila saqinisekiswa yi-PET/CT ngoMeyi 2025.
Njengamanje, kusenezivivinyo eziningi zemitholampilo zobuchwepheshe obusha bokulwa nomdlavuza eShayina ezifuna iziguli. Ukubonisana ngemithi emisha kanye nobuchwepheshe, ungaxhumana noMnyango Wezizwe Ngezizwe Wesibhedlela iBeijing South Region Oncology.
Inombolo yocingo: 4008803716
I-ID ye-WeChat: 17801183037
Email：myimmnet@163.com
I-ATG-022 iyi-CLDN18.2 ADC etholwe futhi yathuthukiswa ngaphakathi yi-Antengene. Engqungqutheleni ye-ASCO GI 2025 ekuqaleni kwalonyaka, i-Antengene yethule idatha yezokwelapha ebuyekeziwe ye-ATG-022. Ezigulini ezine-CLDN18.2 expression ephakathi kuya kwephezulu (IHC 2+ ≥ 20%), izinga lokuphendula eliqondile (ORR) lalingu-42.9%, kanti izinga lokulawula isifo (DCR) lalingu-95.2%. Phakathi kweziguli ezine-CLDN18.2 expression ephansi (IHC 2+ < 20%), i-ORR yayingu-30.0%, kanti i-DCR yayingu-50.0%. Le datha ikhombisa ukuthi i-ATG-022 inikeza ukusebenza kahle okubalulekile emtholampilo kanye nephrofayili yokuphepha enhle kuzo zonke izinhlobo zamazinga okubonakaliswa kwe-CLDN18.2, kufaka phakathi ukubonakaliswa okuphezulu, okuphansi, ngisho nokuphansi kakhulu. Umsebenzi wayo wokulwa nomdlavuza we-spectrum ebanzi usikisela ukuthi i-ATG-022 inganikeza izinzuzo zokwelapha kubantu abaningi abagulayo uma kuqhathaniswa nezinye izindlela zokwelapha eziqondiswe ku-CLDN18.2. Njengamanje, ucwaningo lokwandiswa komthamo weSigaba II lwe-ATG-022 luyaqhubeka ezwenikazi laseShayina nase-Australia.
Lokhu kufezwa kwe-CR kulesi siguli esikhulile esinomdlavuza wesisu kuyakhuthaza kakhulu, kugqamisa amandla okwelapha e-ATG-022 njengokwelashwa okusha kwe-ADC. Okubalulekile, lokhu akuyona yodwa i-CR ebonwe ocwaningweni oluqhubekayo. Kuze kube manje, kuye kwabonwa amacala amathathu e-CR, okuhlanganisa neziguli ezivela ezwenikazi laseShayina nase-Australia. I-Antengene ilangazelela ukwethula idatha ebuyekeziwe evela ocwaningweni lwe-ATG-022 eNgqungqutheleni ezayo ye-ESMO ngo-Okthoba 2025.
Njengamanje, kusenezivivinyo eziningi zemitholampilo zobuchwepheshe obusha bokulwa nomdlavuza eShayina ezifuna iziguli. Ukubonisana ngemithi emisha kanye nobuchwepheshe, ungaxhumana noMnyango Wezizwe Ngezizwe Wesibhedlela iBeijing South Region Oncology.
Inombolo yocingo: 4008803716
I-ID ye-WeChat: 17801183037
Email：myimmnet@163.com
Isikhathi sokuthunyelwe: Agasti-21-2025