Ngo-2021, isiguli esineminyaka engu-67 ubudala esinomdlavuza we-pancreatic senza isimangaliso sezokwelapha. Ngemva kokuhlinzwa, ukuhlinzwa kaningi ngamakhemikhali, kanye nokwehluleka kokwelashwa kwe-TIL, ukuhlolwa kwezokwelapha kwe-TCR-T kwaqala.Ukwelashwa ngamaseli ahlanganyele kukho kwenza ukusabalala kwamaphaphu kwehla ngo-72% zingakapheli izinyanga eziyi-6. Lo mphumela ophumelelayo wanyatheliswa kuyi-New England Journal of Medicine, okuletha ithemba elisha ezigulini ezinezimila eziqinile emhlabeni jikelele.
Isikhungo Sokubonisana Samazwe Ngamazwe saseBeijing South Suburb Oncology Hospital (400 – 880 – 3716) singakha ibhuloho lokunakekelwa kwezokwelapha okuthuthukisiwe kwamazwe ngamazwe kweziguli ngezinsizakusebenza zaso ezicebile zamazwe ngamazwe futhi sidlala indima ebalulekile ekubonisaneni kwamazwe ngamazwe kanye nokwelashwa kwezokwelapha.
Mayelana ne-TCR-TUkwelapha
I-TCR-TUkwelashwa ngamaseli, igama eliphelele elithi i-T – cell receptor engineered T – cell therapy, kuyindlela entsha yokwelapha ngamaseli amukelayo. Umgomo wayo oyinhloko ukukhipha amaseli e-T emzimbeni wesiguli bese wethula i-TCR gene engakwazi ukubona ama-antigen athile esimila kumaseli e-T ngokusebenzisa ubuchwepheshe bobunjiniyela bezakhi zofuzo. Ngenxa yalokho, amaseli e-T aguquliwe angabona futhi abophane ngokunembile nama-antigen ebusweni bamaseli esimila, ngaleyo ndlela asebenze umsebenzi wokubulala amasosha omzimba wamaseli e-T futhi afeze umgomo wokuqeda amaseli esimila.
Indaba Yempumelelo ye-TCR-TUkwelashwa: Isimangaliso Sesiguli Esine-KRAS G12D - Umdlavuza We-Pancreatic Oguquliwe
Ngaphambi kokuxilongwa ukuthi une-pancreatic head adenocarcinoma, lesi siguli esineminyaka engu-67 ubudala sasihlupheke kakhulu ngenxa yokuhlaselwa okuphindaphindiwe kwe-pancreatitis kanye nokuqina kwenyongo. Ngemva kokuxilongwa, sadlula imijikelezo emine yohlelo lwe-FOLFIRINOX neoadjuvant chemotherapy, kwalandela ukuhlinzwa kanye ne-chemotherapy eyengeziwe. Lokhu kwenza isimo saso sakwazi ukulawulwa isikhathi esithile, futhi isimila asizange siqhubekele phambili.
Kodwa-ke, izikhathi ezimnandi azizange zihlale isikhathi eside. Ngo-2019, isiguli saba nomdlavuza wamaphaphu, okungangabazeki ukuthi kwaba yinselele enkulu ekwelashweni. Ngo-2020, wabamba iqhaza ovivinyweni lwezokwelapha lwesimila - ukwelashwa kwe-lymphocyte okungena ngaphakathi, kodwa ezinyangeni eziyisithupha kamuva, izilonda ze-metastatic zamaphaphu zaqhubeka futhi, okubonisa ukuthi izindlela zokwelapha zangaphambilini azisakwazi ukulawula ngempumelelo ukukhula kwesimila.
Ngesikhathi isiguli sicishe siphelelwe yithemba, ngoMeyi 2021, i-US Food and Drug Administration yavuma isicelo esisha socwaningo lwezidakamizwa, esaba yinguquko ebalulekile empilweni yaso - saziswa nge-TCR-T.ukwelashwa ngamaseli. NgoJuni 2021, wathola ukwelashwa ngeseli T egazini elingaphandle. Okumangazayo ukuthi, inyanga eyodwa ngemuva kokufakwa kweseli, izilonda zamaphaphu esiguli zancipha kakhulu, kanti isimila sancipha ngo-62%. Ngemva kwengxenye yonyaka, isimila sase sinciphe ngo-72%.
Lo mphumela omangalisayo wokwelapha ubonisa ngokugcwele amandla amakhulu e-TCR-Tukwelashwa kwamaseli ekwelapheni umdlavuza.
Kubantu abanomdlavuza, ukuthola ukuxilongwa okunembile kanye nohlelo lokwelashwa olungcono kakhulu kubalulekile. Kodwa-ke, ngenxa yokwehluka kwamazinga ezokwelapha kanye nobuchwepheshe ezindaweni ezahlukene, iziguli zingase zingakwazi ukuthola iseluleko sokwelashwa esithuthuke kakhulu endaweni. Ukubonisana kwamazwe ngamazwe kunikeza iziguli ithuba lokuxhumana nochwepheshe bamazwe ngamazwe abaphezulu, okubenza bakwazi ukufunda ngezindlela zakamuva zokwelapha kanye nemiphumela yocwaningo emhlabeni jikelele.
Ngokubonisana kwamazwe ngamazwe, iziguli zingathola ukuhlolwa okuhlukahlukene kochwepheshe abavela emazweni nasezifundeni ezahlukene. Laba ochwepheshe banokuhlangenwe nakho okucebile kwezokwelapha nolwazi lochwepheshe futhi bangahlaziya futhi bahlulele isimo sesiguli ngezindlela ezahlukene ukuze bathuthukise izinhlelo zokwelapha ezenzelwe wena futhi ezinembile.
Ngaphezu kwalokho, ukubonisana kwamazwe ngamazwe kungasiza iziguli ukuthi zifunde ngezinye izivivinyo zemitholampilo kanye nezindlela zokwelapha ezingakenziwa eShayina, okuzinikeza izinketho ezengeziwe zokwelapha.
UMnyango Wezizwe Zonke weBeijing South Suburb Oncology Hospital (400 – 880 – 3716) uyazi kahle ukubaluleka kokubonisana kwamazwe ngamazwe kweziguli ezinomdlavuza. Ngakho-ke, wakha ngenkuthalo ipulatifomu yokushintshana kwezokwelapha yamazwe ngamazwe ukuze unikeze iziguli izinsizakalo zokubonisana zamazwe ngamazwe zobungcweti nezisebenzayo. E-International Department of Beijing South Suburb Oncology Hospital, iziguli zingahlanganyela ekubonisaneni kwamazwe ngamazwe kungaba ku-inthanethi noma ngaphandle kwe-inthanethi. Ithimba lethu lezokwelapha lizoqoqa amarekhodi ezokwelapha esiguli, imibiko yokuhlola kanye nolunye ulwazi kusengaphambili bese liwahumushela esiNgisini ukuqinisekisa ukuthi ochwepheshe bamazwe ngamazwe bangasiqonda ngokugcwele isimo sesiguli. Ngesikhathi sokubonisana, ochwepheshe bamazwe ngamazwe bazoxhumana ubuso nobuso nesiguli, babuze imibuzo eningiliziwe mayelana nomlando wezokwelapha wesiguli, izimpawu, kanye nesimo sokwelashwa, bese behlanganisa imiphumela yakamuva yocwaningo lwezokwelapha kanye nolwazi lwezokwelapha ukuthuthukisa uhlelo lokwelapha olufanele kakhulu lwesiguli.
Ngesikhathi esifanayo, i-International Department of Beijing South Suburb Oncology Hospital izophinde inikeze iziguli izinsizakalo zokuhumusha nokuxhumanisa ezigcwele ukuqinisekisa intuthuko ebushelelezi yokubonisana. Ngemva kokubonisana, sizophendula ngokushesha imiphumela yokubonisana kanye neziphakamiso zokwelashwa esigulini futhi sinikeze isiqondiso nokusekelwa kokwelashwa okulandelayo.
Ukuze iziguli zikwazi ukuthola iziphakamiso zokuxilongwa kanye nokwelashwa kochwepheshe bamazwe ngamazwe ngokushesha okukhulu, i-International Department of Beijing South Suburb Oncology Hospital yenze lula inqubo yesevisi yokubonisana. Iziguli zidinga kuphela ukushayela ucingo ku-400 – 880 – 3716 futhi zinikeze amarekhodi ezokwelapha afanele kanye nemibiko yokuhlolwa. Ithimba lochwepheshe le-International Department of Beijing South Suburb Oncology Hospital lizohlela uchwepheshe wamazwe ngamazwe ofanele ukuze isiguli sixhumane naye ngesikhathi esifushane kakhulu. Ngesikhathi sokubonisana, ithimba lokuhumusha lochwepheshe lizoqinisekisa ukuxhumana okubushelelezi nokunembile phakathi kodokotela neziguli, okuvumela iziguli ukuthi ziqonde ngokucacile imibono neziphakamiso zochwepheshe. Ngaphezu kwalokho, i-International Department of Beijing South Suburb Oncology Hospital ingasiza iziguli ekusingatheni izinqubo zokudlulisela, ukuhlela uhambo, njll., ukuhlinzeka ngezinsizakalo zokuma okukodwa.
Ukwabelana Ngecala Nokuphefumulelwa
Ngaphezu kwesimo esingenhla sesiguli esinomdlavuza we-pancreatic oguquliwe i-KRAS G12D, i-International Department of Beijing South Suburb Oncology Hospital nayo isize iziguli zomdlavuza zakwamanye amazwe ukuthi zithole imiphumela emihle yokwelashwa ngokwelashwa eShayina.
NgoJuni 2024, isiguli somdlavuza wamaphaphu esingesona amangqamuzana amancane esivela eNyakatho Korea safuna usizo lwethu. Umdlavuza wamaphaphu ungomunye wamathumba amabi anezinga eliphezulu kakhulu lokutheleleka emhlabeni jikelele naseShayina. Ngo-2022, kwakunamacala amasha angaba yizigidi eziyi-1.06 kanye nokufa kwabantu abangaba ngu-740,000 ngenxa yomdlavuza wamaphaphu eShayina, phakathi kwawo umdlavuza wamaphaphu ongewona amangqamuzana amancane (i-NSCLC) ubanga cishe u-80% - 85%.
Isiguli sasinokuguqulwa kwe-EGFR futhi sathola ukwelashwa okufana ne-afatinib kanye ne-osimertinib. Nakuba sasithole ukwelashwa okuhlukahlukene ngenkuthalo, izindaba ezimbi zafika ngoMeyi 2024, futhi isimo sesiguli sathuthuka. Ngakho weza eShayina ukuzosisiza.
Ngemva kokuhlolwa, ukubonakaliswa kwe-mesothelin (MSLN) yesiguli kwaba ngu-75%. Sabe sesisiza isiguli ukuthola uhlelo lwakamuva lokwelashwa ezweni lonke. Manje isimo sesiguli sesinciphile, futhi amaqhubu emaphashini anciphile, njengoba kuboniswe esithombeni esingezansi.
Leli cala lisitshela ukuthi ezigulini ezinomdlavuza, akufanele zilahle kalula ithuba lokwelashwa. Ngisho noma ukwelashwa kwasekhaya kuyinkinga, zingaqonda nezindlela zakamuva zokwelapha zamazwe ngamazwe kanye nemiphumela yocwaningo ngokusebenzisa ukubonisana kwamazwe ngamazwe futhi zilwele amathuba engeziwe okwelashwa.
Indlela Yokuxhumana NoMnyango Wezizwe Zonke Wesibhedlela Se-Beijing South Suburb Oncology
Uma wena noma amalungu omndeni wakho nihlushwa umdlavuza futhi ninethemba lokufunda ngezindlela zokwelapha ezisezingeni eliphezulu zamazwe ngamazwe noma nifune iziphakamiso zokuxilongwa nokwelashwa kochwepheshe bamazwe ngamazwe, sicela ushayele inombolo yocingo ye-International Department of Beijing South Suburb Oncology Hospital (400 – 880 – 3716). Ithimba lochwepheshe lizophendula imibuzo yakho, lihlele ukubonisana kwamazwe ngamazwe, futhi likunikeze ukwesekwa okuphelele kanye nosizo.
Ukwelashwa komdlavuza kuyimpi ende futhi enzima, kodwa sikholelwa ukuthi ngentuthuko eqhubekayo yobuchwepheshe bezokwelapha, iziguli eziningi zomdlavuza zizokwazi ukunqoba lesi sifo futhi ziphinde zilulame. Isibhedlela i-International Department of Beijing South Suburb Oncology sizoqhubeka nokulwela ukuthuthukisa njalo izinga laso lenkonzo kanye namakhono ezokwelapha futhi sinikeze izinsizakalo zezokwelapha zomhlaba wonke ezisezingeni eliphezulu ezigulini eziningi zomdlavuza. Masibambisane ukuze silwe nomdlavuza futhi sidale izimangaliso zokuphila!
Njengamanje, kusenezivivinyo eziningi zemitholampilo zobuchwepheshe obusha bokulwa nomdlavuza eShayina ezifuna iziguli. Ukubonisana ngemithi emisha kanye nobuchwepheshe, ungaxhumana noMnyango Wezizwe Ngezizwe Wesibhedlela iBeijing South Region Oncology.
Inombolo yocingo: 4008803716
Email：myimmnet@163.com
Isikhathi sokuthunyelwe: Meyi-15-2025